Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus
Identifieur interne : 004E50 ( Main/Exploration ); précédent : 004E49; suivant : 004E51Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus
Auteurs : Susan R. Weiss [États-Unis] ; Sonia Navas-Martin [États-Unis]Source :
- Microbiology and molecular biology reviews [ 1092-2172 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Bovins, Chats, Coronavirus (génétique), Coronavirus (pathogénicité), Humains, Infections à coronavirus (), Infections à coronavirus (virologie), Modèles animaux de maladie humaine, Protéines virales (génétique), Protéines virales (métabolisme), Souris, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (virologie), Vaccins antiviraux (usage thérapeutique), Virion (ultrastructure), Virus du SRAS (génétique), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Coronavirus, Protéines virales, Virus du SRAS.
- métabolisme : Protéines virales.
- pathogénicité : Coronavirus, Virus du SRAS.
- usage thérapeutique : Vaccins antiviraux, Virion.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Cats, Cattle, Coronavirus, Coronavirus (genetics), Coronavirus (pathogenicity), Coronavirus Infections (prevention & control), Coronavirus Infections (therapy), Coronavirus Infections (virology), Disease Models, Animal, Emerging disease, Humans, Mice, Pathogenesis, Review, SARS Virus (genetics), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (therapy), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Viral Proteins (genetics), Viral Proteins (metabolism), Viral Vaccines (therapeutic use), Virion (ultrastructure).
- MESH :
- chemical , genetics : Viral Proteins.
- genetics : Coronavirus, SARS Virus.
- chemical , metabolism : Viral Proteins.
- pathogenicity : Coronavirus, SARS Virus.
- prevention & control : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- chemical , therapeutic use : Viral Vaccines.
- therapy : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- ultrastructure : Virion.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Animals, Cats, Cattle, Disease Models, Animal, Humans, Mice.
Abstract
Coronaviruses are a family of enveloped single-stranded, positive-strand RNA viruses classified within the Nidovirales order. This coronavirus family consists of pathogens of many animal species and of humans, including the recently isolated severe acute respiratory syndrome coronavirus (SARS-CoV). This review is divided into two main parts; the first concerns the animal coronaviruses and their pathogenesis, with an emphasis on the functions of individual viral genes, and the second discusses the newly described human emerging pathogen, SARS-CoV. The coronavirus part covers (i) a description of a group of coronaviruses and the diseases they cause, including the prototype coronavirus, murine hepatitis virus, which is one of the recognized animal models for multiple sclerosis, as well as viruses of veterinary importance that infect the pig, chicken, and cat, and a summary of the human viruses; (ii) a short summary of the replication cycle of coronaviruses in cell culture; (iii) the development and application of reverse genetics systems; and (iv) the roles of individual coronavirus proteins in replication and pathogenesis. The SARS-CoV part covers the pathogenesis of SARS, the developing animal models for infection, and the progress in vaccine development and antiviral therapies. The data gathered on the animal coronaviruses continue to be helpful in understanding SARS-CoV.
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Affiliations:
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Le document en format XML
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This coronavirus family consists of pathogens of many animal species and of humans, including the recently isolated severe acute respiratory syndrome coronavirus (SARS-CoV). This review is divided into two main parts; the first concerns the animal coronaviruses and their pathogenesis, with an emphasis on the functions of individual viral genes, and the second discusses the newly described human emerging pathogen, SARS-CoV. The coronavirus part covers (i) a description of a group of coronaviruses and the diseases they cause, including the prototype coronavirus, murine hepatitis virus, which is one of the recognized animal models for multiple sclerosis, as well as viruses of veterinary importance that infect the pig, chicken, and cat, and a summary of the human viruses; (ii) a short summary of the replication cycle of coronaviruses in cell culture; (iii) the development and application of reverse genetics systems; and (iv) the roles of individual coronavirus proteins in replication and pathogenesis. The SARS-CoV part covers the pathogenesis of SARS, the developing animal models for infection, and the progress in vaccine development and antiviral therapies. The data gathered on the animal coronaviruses continue to be helpful in understanding SARS-CoV.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R." last="Weiss">Susan R. Weiss</name></region><name sortKey="Navas Martin, Sonia" sort="Navas Martin, Sonia" uniqKey="Navas Martin S" first="Sonia" last="Navas-Martin">Sonia Navas-Martin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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